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主要成份：
葡萄籽萃取物 葡萄籽萃取物是從紅葡萄的籽（而非白葡萄）萃取的精華，包含了大量原花色素(OPCs)。葡萄籽富含多酚類複合物，對人體有許多益處。
紅酒萃取物 紅酒萃取物富含有益的活性成分。葡萄藤、葡萄根、葡萄籽和莖都可以發現類黃酮，但葡萄皮含有最高濃度的類黃酮。90年代末期，科學家注意到一個法國特有的現象。研究發現，法國某些省份的居民經常食用高脂肪食物和飲用紅酒，卻仍能維持健康。科學家歸結，是因為紅酒裡面含有的成分，幫助法國人維持多年健康。隨後的科學研究更進一步證實，在紅酒裡發現的OPC有益於維持人體健康。
松樹皮萃取物（碧蘿芷，Pycnogenol®） 碧蘿芷(Pycnogenol®)是由海岸松樹皮萃取的天然植物萃取物，這種海岸松只生長在法國西南部沿岸的加斯科尼地區。這片不受污染的天然樹林就是碧蘿芷的唯一來源。碧蘿芷是天然產品巿場上，最受廣泛研究的成份之一。發表的研究報告顯示，碧蘿芷以天然方式結合原花青素、生物類黃酮及有機酸，對身體健康有許多好處。
山桑萃取物 山桑萃取物取自歐洲一種普遍的矮灌木的葉與果實，這種植物與藍莓非常相似。
成熟的山桑莓果含有稱為花青素的類黃酮色素。許多國外科學研究證明，山桑萃取物能讓身體健康循環，並且提升新陳代謝。
柑橘類萃取物（生物類黃酮） 生物類黃酮存在於某些植物，用來當做植物的光過濾器、負責吸收紫外線，保護植物避免受到傷害。
鉀（重碳酸鉀） 富含鉀的食物包括了新鮮蔬果，例如香蕉、柳丁、哈蜜瓜、鱷梨、生菠菜、甘藍菜和芹菜。
鉀是幫助維持體液平衡的必需巨量礦物質。在眾多生化和生理過程中，鉀都扮演重要的角色。鉀調節並維持體內的水平衡。鉀參與醣類代謝，並和鈉、鎂、鈣共同維持心臟、肌肉及神經的正常功能。
In the News:
Grape Seed Extract for Blood Pressure?
SOURCES: American Chemical Society National Meeting & Exposition, Atlanta, March 26-30, 2006. Tissa Kappagoda, MD, PhD, professor of internal medicine (cardiovascular medicine), University of California, Davis. News release, University of California, Davis. News release, American Chemical Society.
Scientific Studies: o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999. o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004. o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004. o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004. o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000. o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003. o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004. o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19. o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002. o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003. o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001. o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999. o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004. o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996. o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002. o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003. o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997. o Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999. o Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993. o Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997. o Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000. o Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002. o Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993. o Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002. o Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991. o Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990. o Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983. o Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998. o Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999. o Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002. o Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993. o Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002. o Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990. o Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002. o Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995. o Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991. o Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995. o Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999. o Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984. o Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988. o Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995. 此產品為何與眾不同？
愛尚它®葡萄籽、松樹皮、紅酒萃取精華是具有等滲透特性的補充品，內含山桑、葡萄籽、紅酒、松樹皮萃取物和柑橘生物類黃酮等多種含有OPC（原花色素低聚物）的植物成份。OPC可以提供人體卓越廣泛的營養益處，其中包含了調整體質、維持身體機能、養顏美容、幫助健康和延年益壽，以及提昇新陳代謝。
OPC是植物複合物，也就是存在於水果、蔬菜和特定樹皮中的生物類黃酮，可以提供人體卓越廣泛的營養益處。研究顯示，原花色素的功效是維生素C和維生素E的好幾倍。愛尚它®葡萄籽、松樹皮、紅酒萃取精華含有全世界唯一等滲透形式的碧蘿芷(Pycnogenol®)。碧蘿芷是一種天然植物萃取物，萃取自法國的海岸松樹皮，是目前廣為研究的生物類黃酮。
等滲透表示「相等的壓力」，和身體血液、血漿和眼淚的液體化學性壓力相似。身體的體液都有特定濃度，也就是滲透壓。身體正常的滲透壓，稱之為等滲透壓，讓身體組織能維持平衡。
愛尚它®膳食營養補充品是以等滲透溶液方式傳輸。愛尚它產品讓營養價值不流失，有效率的獲得營養素。 常見問題：
1. 抗凝血劑(Warfarin)、阿斯匹靈或其他常用的藥品可以與OPC-3併用嗎? 假如您正服用處方藥品，我們建議您先諮詢醫師，主動告訴醫師您食用含生物類黃酮的食品。
2. 為何在食用OPC-3之後，我的胃感到不舒服（有時候會逆流）？ 有些人對於愛尚它產品中的檸檬酸成分比較敏感，因而感到逆流。建議可以食用較少份量（或分次使用）OPC-3，或先諮詢您的醫師。
3. 進行手術前可食用OPC-3嗎？ 我們建議您先諮詢醫師。
4. OPC-3的成分（松樹皮、越橘和葡萄籽萃取物）都沒有殺蟲劑殘留嗎？ 沒錯，所有萃取自天然植物的成分（像是松樹皮、柑橘、越橘、葡萄籽和葡萄皮萃取物）都透過氣相層析儀檢驗是否有殺蟲劑殘留，所以都無殺蟲劑。
5. 既然OPC-3如此出眾，那麼為何也需要愛尚它®ATX 配方？ 食用多種不同的營養補充品很重要，因為不同的補充品在體內作用的地方不同。您可以同時使用愛尚它®ATX配方和愛尚它®葡萄籽、松樹皮、紅酒萃取精華，如此可以幫助您維持各方面的生理健康。
6. 什麼是OPC-3®？ OPC-3是一種天然膳食補充品，含有的活性成份是現今所稱的生物類黃酮。這些生物類黃酮的學名為oligomeric proanthocyanidins，簡稱OPC，也就是原花色素，萃取自葡萄籽、紅酒、山桑、柑橘類水果，還有取自松樹皮的碧蘿芷。這種原花色素的組合與愛尚它的等滲透傳輸系統，讓人體有效補充原花色素。愛尚它OPC-3對健康有許多好處。
7. 什麼是生物類黃酮？ 生物類黃酮是植物性有機複合物。植物和水果擁有不同的顏色，是因為各含不同的生物類黃酮。生物類黃酮在營養學上扮演重要的角色。愈來愈多的臨床研究顯示，生物類黃酮對人體健康具有多重益處。
8. 食用OPC-3®安全嗎？ 是的！原花色素是人類健康飲食中最寶貴的成份之一。歐洲人研究並使用原花色素已逾三十年之久。OPC-3含有純淨的原花色素，加上謹慎調配的鉀及少量糖份，組成了等滲透系統。OPC-3不含有害的化學物質、防腐劑及酒精。請依照指示飲用。
9. 食用愛尚它OPC-3時，可以以汽水、果汁或咖啡等飲料來代替水嗎？ 可以，但我們並不建議這樣飲用。產品應該依照指示食用。為了保持產品的等滲透狀態，每瓶蓋OPC-3請搭配60毫升的水空腹飲用。如果以其它飲料來混和食用，會減緩傳送速度，並可能影響吸收率。
10. 如何食用OPC-3？ 每瓶蓋的愛尚它OPC-3等滲溶液含有125毫克的生物類黃酮，其中有75毫克是原花色素。
愛尚它®葡萄籽、松樹皮、紅酒萃取精華(OPC-3®)有美味的葡萄香味，即溶於水，且為全素產品。建議空腹食用，使活性成分能更有效傳輸。愛尚它®葡萄籽、松樹皮、紅酒萃取精華(OPC-3®)是天然營養補充品，應該持續食用。
11. 原花色素(OPCs)的歷史淵源為何？ 1534年，法國探險家傑克．卡迪耶 (Jacques Cartier)在聖羅倫斯河率領遠征隊執行任務。由於天氣惡劣，卡迪耶和隊員必須靠著配給的鹹肉和餅乾維持生存。卡迪耶的隊員因為嚴重缺乏維生素C，所以開始出現壞血病症狀。許多隊員因此去世，隨後存活的隊員遇到一位友善的印第安原住民。他告知隊員使用松樹皮和松針煮茶飲用。他們如法炮製，結果卡迪耶和許多隊員因此恢復健康。
主要效益：
l 調整體質和生理功能 l 維持身體機能 l 改善氣色 l 維持健康，延年益壽 l 提昇新陳代謝
主要成份：
葡萄籽萃取物 葡萄籽萃取物是從紅葡萄的籽（而非白葡萄）萃取的精華，包含了大量原花色素(OPCs)。葡萄籽富含多酚類複合物，對人體有許多益處。
紅酒萃取物 紅酒萃取物富含有益的活性成分。葡萄藤、葡萄根、葡萄籽和莖都可以發現類黃酮，但葡萄皮含有最高濃度的類黃酮。90年代末期，科學家注意到一個法國特有的現象。研究發現，法國某些省份的居民經常食用高脂肪食物和飲用紅酒，卻仍能維持健康。科學家歸結，是因為紅酒裡面含有的成分，幫助法國人維持多年健康。隨後的科學研究更進一步證實，在紅酒裡發現的OPC有益於維持人體健康。
松樹皮萃取物（碧蘿芷，Pycnogenol®） 碧蘿芷(Pycnogenol®)是由海岸松樹皮萃取的天然植物萃取物，這種海岸松只生長在法國西南部沿岸的加斯科尼地區。這片不受污染的天然樹林就是碧蘿芷的唯一來源。碧蘿芷是天然產品巿場上，最受廣泛研究的成份之一。發表的研究報告顯示，碧蘿芷以天然方式結合原花青素、生物類黃酮及有機酸，對身體健康有許多好處。
山桑萃取物 山桑萃取物取自歐洲一種普遍的矮灌木的葉與果實，這種植物與藍莓非常相似。
成熟的山桑莓果含有稱為花青素的類黃酮色素。許多國外科學研究證明，山桑萃取物能讓身體健康循環，並且提升新陳代謝。
柑橘類萃取物（生物類黃酮） 生物類黃酮存在於某些植物，用來當做植物的光過濾器、負責吸收紫外線，保護植物避免受到傷害。
鉀（重碳酸鉀） 富含鉀的食物包括了新鮮蔬果，例如香蕉、柳丁、哈蜜瓜、鱷梨、生菠菜、甘藍菜和芹菜。
鉀是幫助維持體液平衡的必需巨量礦物質。在眾多生化和生理過程中，鉀都扮演重要的角色。鉀調節並維持體內的水平衡。鉀參與醣類代謝，並和鈉、鎂、鈣共同維持心臟、肌肉及神經的正常功能。
In the News:
Grape Seed Extract for Blood Pressure?
SOURCES: American Chemical Society National Meeting & Exposition, Atlanta, March 26-30, 2006. Tissa Kappagoda, MD, PhD, professor of internal medicine (cardiovascular medicine), University of California, Davis. News release, University of California, Davis. News release, American Chemical Society.
Scientific Studies: o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000. o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994. o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000. o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001. o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002. o Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998. o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993. o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001. o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000. o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999. o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999. o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004. o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004. o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004. o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000. o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003. o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997. o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001. o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004. o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998. o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review. o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review. o Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19. o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002. o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999. o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998. o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002. o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002. o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004. o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review. o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003. o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001. o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999. o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004. o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996. o Wallerath, T., et al. 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Toxicology 148: 187-97, 2000. o Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002. o Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993. o Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002. o Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991. o Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990. o Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983. o Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. 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Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995. 此產品為何與眾不同？
愛尚它®葡萄籽、松樹皮、紅酒萃取精華是具有等滲透特性的補充品，內含山桑、葡萄籽、紅酒、松樹皮萃取物和柑橘生物類黃酮等多種含有OPC（原花色素低聚物）的植物成份。OPC可以提供人體卓越廣泛的營養益處，其中包含了調整體質、維持身體機能、養顏美容、幫助健康和延年益壽，以及提昇新陳代謝。
OPC是植物複合物，也就是存在於水果、蔬菜和特定樹皮中的生物類黃酮，可以提供人體卓越廣泛的營養益處。研究顯示，原花色素的功效是維生素C和維生素E的好幾倍。愛尚它®葡萄籽、松樹皮、紅酒萃取精華含有全世界唯一等滲透形式的碧蘿芷(Pycnogenol®)。碧蘿芷是一種天然植物萃取物，萃取自法國的海岸松樹皮，是目前廣為研究的生物類黃酮。
等滲透表示「相等的壓力」，和身體血液、血漿和眼淚的液體化學性壓力相似。身體的體液都有特定濃度，也就是滲透壓。身體正常的滲透壓，稱之為等滲透壓，讓身體組織能維持平衡。
愛尚它®膳食營養補充品是以等滲透溶液方式傳輸。愛尚它產品讓營養價值不流失，有效率的獲得營養素。 常見問題：
1. 抗凝血劑(Warfarin)、阿斯匹靈或其他常用的藥品可以與OPC-3併用嗎? 假如您正服用處方藥品，我們建議您先諮詢醫師，主動告訴醫師您食用含生物類黃酮的食品。
2. 為何在食用OPC-3之後，我的胃感到不舒服（有時候會逆流）？ 有些人對於愛尚它產品中的檸檬酸成分比較敏感，因而感到逆流。建議可以食用較少份量（或分次使用）OPC-3，或先諮詢您的醫師。
3. 進行手術前可食用OPC-3嗎？ 我們建議您先諮詢醫師。
4. OPC-3的成分（松樹皮、越橘和葡萄籽萃取物）都沒有殺蟲劑殘留嗎？ 沒錯，所有萃取自天然植物的成分（像是松樹皮、柑橘、越橘、葡萄籽和葡萄皮萃取物）都透過氣相層析儀檢驗是否有殺蟲劑殘留，所以都無殺蟲劑。
5. 既然OPC-3如此出眾，那麼為何也需要愛尚它®ATX 配方？ 食用多種不同的營養補充品很重要，因為不同的補充品在體內作用的地方不同。您可以同時使用愛尚它®ATX配方和愛尚它®葡萄籽、松樹皮、紅酒萃取精華，如此可以幫助您維持各方面的生理健康。
6. 什麼是OPC-3®？ OPC-3是一種天然膳食補充品，含有的活性成份是現今所稱的生物類黃酮。這些生物類黃酮的學名為oligomeric proanthocyanidins，簡稱OPC，也就是原花色素，萃取自葡萄籽、紅酒、山桑、柑橘類水果，還有取自松樹皮的碧蘿芷。這種原花色素的組合與愛尚它的等滲透傳輸系統，讓人體有效補充原花色素。愛尚它OPC-3對健康有許多好處。
7. 什麼是生物類黃酮？ 生物類黃酮是植物性有機複合物。植物和水果擁有不同的顏色，是因為各含不同的生物類黃酮。生物類黃酮在營養學上扮演重要的角色。愈來愈多的臨床研究顯示，生物類黃酮對人體健康具有多重益處。
8. 食用OPC-3®安全嗎？ 是的！原花色素是人類健康飲食中最寶貴的成份之一。歐洲人研究並使用原花色素已逾三十年之久。OPC-3含有純淨的原花色素，加上謹慎調配的鉀及少量糖份，組成了等滲透系統。OPC-3不含有害的化學物質、防腐劑及酒精。請依照指示飲用。
9. 食用愛尚它OPC-3時，可以以汽水、果汁或咖啡等飲料來代替水嗎？ 可以，但我們並不建議這樣飲用。產品應該依照指示食用。為了保持產品的等滲透狀態，每瓶蓋OPC-3請搭配60毫升的水空腹飲用。如果以其它飲料來混和食用，會減緩傳送速度，並可能影響吸收率。
10. 如何食用OPC-3？ 每瓶蓋的愛尚它OPC-3等滲溶液含有125毫克的生物類黃酮，其中有75毫克是原花色素。
愛尚它®葡萄籽、松樹皮、紅酒萃取精華(OPC-3®)有美味的葡萄香味，即溶於水，且為全素產品。建議空腹食用，使活性成分能更有效傳輸。愛尚它®葡萄籽、松樹皮、紅酒萃取精華(OPC-3®)是天然營養補充品，應該持續食用。
11. 原花色素(OPCs)的歷史淵源為何？ 1534年，法國探險家傑克．卡迪耶 (Jacques Cartier)在聖羅倫斯河率領遠征隊執行任務。由於天氣惡劣，卡迪耶和隊員必須靠著配給的鹹肉和餅乾維持生存。卡迪耶的隊員因為嚴重缺乏維生素C，所以開始出現壞血病症狀。許多隊員因此去世，隨後存活的隊員遇到一位友善的印第安原住民。他告知隊員使用松樹皮和松針煮茶飲用。他們如法炮製，結果卡迪耶和許多隊員因此恢復健康。
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